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what is pregabalin cas148553-50-8
Pregabalin is a drug mainly used to treat nerve pain, epilepsy, and anxiety. It is sold under the brand name Lyrica and was first approved by the U.S. Food and Drug Administration (FDA) in 2004. Since then, pregabalin has become a widely used drug in the treatment of a variety of diseases. This article will discuss the pharmacology, clinical uses, side effects, and potential for abuse of pregabalin.

Pharmacology

Pregabalin belongs to a class of drugs called anticonvulsants. It works by binding to a specific type of receptor in the brain called the alpha-2-delta subunit of voltage-gated calcium channels. This binding reduces the release of several neurotransmitters, including glutamate, substance P, and norepinephrine, resulting in decreased neuronal excitability and pain perception.

Pregabalin is rapidly absorbed after oral administration, with peak plasma concentrations occurring within one to two hours. The drug is mainly excreted in urine with an elimination half-life of about 6 hours. Pregabalin is not extensively metabolized in the liver, nor does it interact with cytochrome P450 enzymes, which are responsible for metabolizing many other drugs.

clinical use

Pregabalin is mainly used to treat nerve pain, including diabetic neuropathy, postherpetic neuralgia, and pain caused by spinal cord injury. It is also used as an adjunctive treatment for partial-onset seizures in adults with epilepsy. Additionally, pregabalin has been shown to be effective in the treatment of generalized anxiety disorder (GAD) and social anxiety disorder (SAD).

neuropathic pain

Several randomized controlled trials have demonstrated the effectiveness of pregabalin in the treatment of neuropathic pain.In a study of patients with painful diabetic neuropathy, pregabalin was shown to be more effective than placebo in reducing pain scores and improving sleep quality